This is a very difficult fish to keep in the aquarium setting by any other than the most experienced aquarist. It should have a minimum of a 180 gallon tank. Use caution if placing the Boxfish in a reef tank as they will often nibble at tubeworms. When stressed, the Boxfish releases a poisonous substance, called ostracitoxin, from its mucous glands which will kill other fish in the tank very quickly.
Very little success has been achieved in breeding these fish in an aquarium. When first introduced, the Boxfish can be fed a diet of live brine shrimp or bloodworms. After acclimatization, chopped squid, clams, mussels, and herbivore preparations can be fed.